Anti-Mouse CD11b, APC, Clone M1/70

Anti-Mouse CD11b, APC, Clone M1/70

SKU Description Size Price Shipping  
JWF1004 Anti-Mouse CD11b, APC, Clone M1/70  100 µg $230 Immediate Add To Shopping Cart
Datasheet
DescriptionThe M1/70 monoclonal antibody reacts with the 170kDa a[M] chain of Mac-1 (CD11b/CD18, a[M]ß[2] integrin). It is also known as complement receptor 3(CR3) that mediates adhesion to C3bi and ICAM-1 (CD54). Mac-1 is expressed on macrophages, NK cells, granulocytes, activated lymphocytes and mouse B-1 cells in the peritoneal cavity. Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. Cross-reaction of mAb M1/70 with CD11b on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported. Through interactions with its ligands, CD11b participates in adhesive cell interactions. This antibody is routinely tested by flow cytometric analysis to ensure the product quality.
Gene ID16409
Gene NameITGAM
AliasNot listed
Host SpeciesRat
Reactivity SpeciesMouse
ClonalityMonoclonal
Clone Number M1/70
IsotypeIgG2b, kappa
ConjugationAPC
Concentration
FormulationPBS pH 7.2, 0.09% NaN3,0.2% BSA
Purification MethodAntibody was purified by affinity chromatography and conjugated with dye. The conjugated antibody was polished with chromatography and is free of unconjugated dye and unconjugated antibody.
ApplicationsFlow Cytometry
Suggested DilutionsSuggested amount of the reagent to be used: Less than 1.0 µg per million cells in 100 µl volume. Optimal dilutions must be determined by end users.
Storage ConditionsStore at 4°C and protect from light. DO NOT FREEZE. Stable for at least six months from date of shipment.
Shipping ConditionsAt Ambient Temperature
BackgroundThis gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene
This product was manufactured by QuantoBio Inc.
Antibody Image
C57BL/6 bone marrow cells were stained with APC Anti-Mouse CD11b antibody.