Anti-Human CD42b, FITC, Clone HIP1

Anti-Human CD42b, FITC, Clone HIP1

SKU Description Size Price Shipping  
JWF1011 Anti-Human CD42b, FITC, Clone HIP1  100T $160 Immediate Add To Shopping Cart
Datasheet
DescriptionThe HIP1 monoclonal antibody reacts with the human CD42b molecule, a 135 kDa transmembrane protein also known as platelet gpIb. It is composed in a heterodimer with a ß chain (CD42c, gpIbß) through a disulfide bond. CD42b is expressed on platelets and megakaryocytes. CD42b/c heterodimer forms a complex with CD42a and d and acts as the receptor for Von Willibrand factor and thrombin. This antibody is routinely tested by flow cytometric analysis to ensure the product quality.
Gene ID2811
Gene NameGP1BA
AliasNot listed
Host SpeciesMouse
Reactivity SpeciesHuman
ClonalityMonoclonal
Clone Number HIP1
IsotypeIgG1, kappa
ConjugationFITC
ConcentrationPre-tested ready-to-use solution
FormulationPBS pH 7.2, 0.09% NaN3,0.2% BSA
Purification MethodAntibody was purified by affinity chromatography and conjugated with dye. The conjugated antibody was polished with chromatography and is free of unconjugated dye and unconjugated antibody.
ApplicationsFlow Cytometry
Suggested DilutionsSuggested amount of the reagent to be used: 10 µL antibody for a million cells or 100 µl human whole blood. Optimal dilutions must be determined by end users.
Storage ConditionsStore at 4°C and protect from light. DO NOT FREEZE. Stable for at least six months from date of shipment.
Shipping ConditionsAt Ambient Temperature
BackgroundGlycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. 
This product was manufactured by QuantoBio Inc.
Antibody Image
The Human peripheral blood platelets were stained with FITC Mouse Anti-Human CD42b antibody (filled histogram) or the isotype control antibody (open histogram)