Anti-Human CD45RA, APC, Clone HI100

Anti-Human CD45RA, APC, Clone HI100

SKU Description Size Price Shipping  
JWF1013 Anti-Human CD45RA, APC, Clone HI100  100T $240 Immediate Add To Shopping Cart
Datasheet
DescriptionThe HI100 monoclonal antibody reacts with human CD45RA, a 220 kDa isoform of the human leukocyte common antigen. The CD45RA isoform is expressed on resting/naive T cells, medullary thymocytes, B cells and monocytes. CD45RA enhances both T cell receptor and B cell receptor signaling. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. This antibody is routinely tested by flow cytometric analysis to ensure the product quality.
Gene ID5788
Gene NamePTPRC
AliasNot listed
Host SpeciesMouse
Reactivity SpeciesHuman
ClonalityMonoclonal
Clone Number HI100
IsotypeIgG2b, kappa
ConjugationAPC
ConcentrationPre-tested ready-to-use solution
FormulationPBS pH 7.2, 0.09% NaN3,0.2% BSA
Purification MethodAntibody was purified by affinity chromatography and conjugated with dye. The conjugated antibody was polished with chromatography and is free of unconjugated dye and unconjugated antibody.
ApplicationsFlow Cytometry
Suggested DilutionsSuggested amount of the reagent to be used: 10 µL antibody for a million cells or 100 µl human whole blood. Optimal dilutions must be determined by end users.
Storage ConditionsStore at 4°C and protect from light. DO NOT FREEZE. Stable for at least six months from date of shipment.
Shipping ConditionsAt Ambient Temperature
BackgroundThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. 
This product was manufactured by QuantoBio Inc.
Antibody Image
The Human whole blood cells were stained with APC Mouse Anti-Human CD45RA antibody and PE Mouse Anti-Human CD45RO antibody.