Mouse anti-human CD35/CR1 monoclonal antibody, clone KT23

Mouse anti-human CD35/CR1 monoclonal antibody, clone KT23

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WZA1004 Mouse anti-human CD35/CR1 monoclonal antibody, clone KT23 100 µg $298 2-7 days Add To Shopping Cart
Datasheet
DescriptionMouse anti-human CD35/CR1 monoclonal antibody, clone KT23
Gene ID1378
Gene NameCR1
AliasKN; C3BR; C4BR; CD35
Host SpeciesMouse
Reactivity SpeciesHuman
ClonalityMonoclonal
Clone Number KT23
IsotypeIgG
ConjugationNone
Concentration1 mg/ml
FormulationPBS pH 7.2, 0.09% NaN3,0.2% BSA
Purification MethodAntibody was purified by affinity chromatography with Protein A column.
ApplicationsWB, IP, ELISA
Suggested DilutionsFinal dilution for use is application-dependent and need to be determined by the end users. A final concentration of 1ug/ml is recommended as a starting point for most applications.
Storage ConditionsStore at 4°C. The antibody is stable for at least six months from date of shipment. For long-term storage, aliquote the antibody and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Shipping ConditionsAt ambient temperature, or with blue ice.
BackgroundThis gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.
Antibody Image