Mouse anti-human CFI/Complement factor I monoclonal antibody, Clone KT22

Mouse anti-human CFI/Complement factor I monoclonal antibody, Clone KT22

SKU Description Size Price Shipping  
WZA1026 Mouse anti-human CFI/Complement factor I monoclonal antibody, Clone KT22 100 µg $298 2-7 days Add To Shopping Cart
Datasheet
DescriptionMouse anti-human CFI/Complement factor I monoclonal antibody, Clone KT22
Gene ID3426
Gene NameCFI
AliasFI; IF; KAF; AHUS3; C3BINA; C3b-INA
Host SpeciesMouse
Reactivity SpeciesHuman
ClonalityMonoclonal
Clone Number KT22
IsotypeIgG
ConjugationNone
Concentration1 mg/ml
FormulationPBS pH 7.2, 0.09% NaN3,0.2% BSA
Purification MethodAntibody was purified by affinity chromatography with Protein A column.
ApplicationsWB, IP, ELISA
Suggested DilutionsFinal dilution for use is application-dependent and need to be determined by the end users. A final concentration of 1ug/ml is recommended as a starting point for most applications.
Storage ConditionsStore at 4°C. The antibody is stable for at least six months from date of shipment. For long-term storage, aliquote the antibody and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Shipping ConditionsAt ambient temperature, or with blue ice.
BackgroundThis gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene.
Antibody Image