| Datasheet | |
| Description | Rat anti-human APC monoclonal antibody, Clone KT45 |
| Gene ID | 324 |
| Gene Name | APC |
| Alias | GS; DP2; DP3; BTPS2; DP2.5; PPP1R46 |
| Host Species | Rat |
| Reactivity Species | Human |
| Clonality | Monoclonal |
| Clone Number | KT45 |
| Isotype | IgG |
| Conjugation | None |
| Concentration | 1 mg/ml |
| Formulation | PBS pH 7.2, 0.09% NaN3,0.2% BSA |
| Purification Method | Antibody was purified by affinity chromatography with Protein A column. |
| Applications | WB, IP, ELISA |
| Suggested Dilutions | Final dilution for use is application-dependent and need to be determined by the end users. A final concentration of 1ug/ml is recommended as a starting point for most applications. |
| Storage Conditions | Store at 4°C. The antibody is stable for at least six months from date of shipment. For long-term storage, aliquote the antibody and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Shipping Conditions | At ambient temperature, or with blue ice. |
| Background | This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. |