Recombinant CD3 Proteins - SPEED BioSystems

Recombinant CD3 Proteins

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Cytokines

CD3 is a coponent of T cell receptor complex, which is composed of CD3, TCR and Zeta chain. TCR complex recognizes foreign antigens presented on antigen-presenting cells (such as dendritic cells, B cells and macrophages) and acivates a cascade of signals within the cell, which leads to T cell activation. T cell activation is an important component of immunological resonse against foreign pathogens. However, excessive T cell activation can also lead to autoimmune diseases, such as type 1 diabetes. CD3 itself is also a protein complex composed of four chains: one CD3 gamma chain, one CD3 delta chain and two CD3 epsilon chains. Different CD3 subunit chains can be grafted to antibodies to created artifical chimeric antigen receptors (CARs). These receptors can mimic TCR complex, but recognizes antigens specified by antibody components. CARs can be engineered to recognize virtually any antigen, thus it is a very promising technology for treating varioius diseases, especially cancers.

SPEED Biosystems provides the following forms of high quality recombinant CD3 component proteins.


SKU Protein Name Species Amino Acid Sequence Production Host Tags
YCP1089 CD3 delta Human Phe22-Ala105 of UniProt P04234 HEK293 His
YCP5193 CD3 delta Cynomolgus Phe22-Ala105 of UniProt Q95LI8 HEK293 His
YCP1525 CD3 epsilon Human Asp23-Asp126 of UniProt P07766 HEK293 His
YSP5661 CD3 epsilon Human Asp23-Asp126 of UniProt P07766 HEK293 Fc
YCP5204 CD3 epsilon Human Asp23-Asp126 of UniProt P07766 HEK293 His and Fc
YCP5206 CD3 epsilon Human Asp23-Asp126 of UniProt P07766 HEK293 Strep
YCP5200 CD3 epsilon Cynomolgus Gln22-Asp117 of UniProt Q95LI5 HEK293 His
YCP5202 CD3 epsilon Cynomolgus Gln22-Asp117 of UniProt Q95LI5 HEK293 His and Fc
YCP6019 CD3 epsilon Mouse Asp23-Asp108 of UniProt P22646 HEK293 Fc
YCP5197 CD3D/CD3E dimer Human HEK293 CD3D-Fc/CD3E-His
YCP5199 CD3D/CD3E dimer Human HEK293 CD3D/CD3E-His
YCP5195 CD3D/CD3E dimer Cynomolgus HEK293 CD3D-Flag/CD3E-His
YCP6021 CD3E/CD3G dimer Human HEK293 CD3E-Fc-His/CD3G-Fc-Flag