Human NR1H3/LXRA Protein, Made in E.coli, with His Tag

Human NR1H3/LXRA Protein, Made in E.coli, with His Tag

SKU Description Size Price Shipping  
OP10451 Human NR1H3/LXRA Protein, Made in E.coli, with His Tag 10µg $269 Immediate Add To Shopping Cart
OP10452 Human NR1H3/LXRA Protein, Made in E.coli, with His Tag 25µg $537 Immediate Add To Shopping Cart
Other VersionsNR1H3, with His Tag
NR1H3, with GST Tag
NR1H3 (N-terminal domain [AA1-182]), with His Tag
NR1H3 (Ligand binding domain [AA215-667]), with His Tag
NR1H3 (Ligand binding domain [AA215-667]), with GST Tag
Datasheet
DescriptionLiver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids . There are two subtypes of LXRs, LXRa and LXRß. LXRß is preferentially expressed in liver, small intestine, kidney and spleen . In contrast, LXRa expression is ubiquitous . The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system . Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function . LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes (6-8), including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP) (9-10). LXRa is thought to play a major role in the control of cholesterol catabolism by stimulating the expression of cholesterol 7 alpha-hydroxylase (CYP7A1), the rate limiting enzyme of bile acid synthesis .
Gene ID10062
Gene NameNR1H3
AliasLXR-a, LXRA
Host SpeciesHuman
Production HostE.coli
TagsHis Tag
Purity> 95% as determined by SDS-PAGE
Bio Activity1 unit equals 1 nanogram of purified protein. 20 units are sufficient for a gel-mobility shift assay and 100 units are sufficient for a protein-protein interaction assay.
EndotoxinNot Tested
Formulation20 mM Tris-Cl (pH 7.9) 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA
Concentration100 µg/ml
ReconsitutionAlready in liquid form.
Storage-80 °C
ShippingDry Ice
Background
GenBank Accession #: NM_005693
Amino Acid Sequence:
SLWLGAPVPD IPPDSAVELW KPGAQDASSQ AQGGSSCILR EEARMPHSAG GTAGVGLEAA EPTALLTRAE PPSEPTEIRP QKRKKGPAPK MLGNELCSVC GDKASGFHYN VLSCEGCKGF FRRSVIKGAH YICHSGGHCP MDTYMRRKCQ ECRLRKCRQA GMREECVLSE EQIRLKKLKR QEEEQAHATS LPPRRSSPPQ ILPQLSPEQL GMIEKLVAAQ QQCNRRSFSD RLRVTPWPMA PDPHSREARQ QRFAHFTELA IVSVQEIVDF AKQLPGFLQL SREDQIALLK TSAIEVMLLE TSRRYNPGSE SITFLKDFSY NREDFAKAGL QVEFINPIFE FSRAMNELQL NDAEFALLIA ISIFSADRPN VQDQLQVERL QHTYVEALHA YVSIHHPHDR LMFPRMLMKL VSLRTLSSVH SEQVFALRLQ DKKLPPLLSE IWDVHE
Protein Image