Human NR1H2 Protein, Made in E.coli, with His Tag

Human NR1H2 Protein, Made in E.coli, with His Tag

SKU Description Size Price Shipping  
OP10461 Human NR1H2 Protein, Made in E.coli, with His Tag 10µg $269 Immediate Add To Shopping Cart
OP10462 Human NR1H2 Protein, Made in E.coli, with His Tag 25µg $537 Immediate Add To Shopping Cart
Other VersionsNR1H2, with His Tag
NR1H2, with GST Tag
NR1H2 (Ligand Binding Domain [AA211-461]), with His Tag
NR1H2 (Ligand Binding Domain [AA211-461]), with GST Tag
Datasheet
DescriptionLiver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids . There are two subtypes of LXRs, LXRa and LXRß. LXRa is preferentially expressed in liver, small intestine, kidney and spleen . In contrast, LXRß expression is ubiquitous . The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system . Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function . LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes (6-8), including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP) (9-10). LXRß expressed in livers of LXRa knockout mice does not compensate for the loss of LXRa . In addition, LXRß, but not LXRa, is also able to activate transcription of a reporter gene, which contains a specific direct repeat separated by 1 bp (DR1) element in the promoter, suggesting that LXRß may have different biological functions .
Gene ID7376
Gene NameNR1H2
AliasLXR-b, LXRB
Host SpeciesHuman
Production HostE.coli
TagsHis Tag
Purity> 95% as determined by SDS-PAGE
Bio Activity1 unit equals 1 nanogram of purified protein. 20 units are sufficient for a gel-mobility shift assay and 100 units are sufficient for a protein-protein interaction assay.
EndotoxinNot Tested
Formulation20 mM Tris-Cl (pH 7.9) 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA
Concentration400 µg/ml
ReconsitutionAlready in liquid form.
Storage-80 °C
ShippingDry Ice
Background
GenBank Accession #: NM_007121
Amino Acid Sequence:
MSSPTTSSLD TPLPGNGPPQ PGAPSSSPTV KEEGPEPWPG GPDPDVPGTD EASSACSTDW VIPDPEEEPE RKRKKGPAPK MLGHELCRVC GDKASGFHYN VLSCEGCKGF FRRSVVRGGA RRYACRGGGT CQMDAFMRRK CQQCRLRKCK EAGMREQCVL SEEQIRKKKI RKQQQQESQS QSQSPVGPQG SSSSASGPGA SPGGSEAGSQ GSGEGEGVQL TAAQELMIQQ LVAAQLQCNK RSFSDQPKVT PWPLGADPQS RDARQQRFAH FTELAIISVQ EIVDFAKQVP GFLQLGREDQ IALLKASTIE IMLLETARRY NHETECITFL KDFTYSKDDF HRAGLQVEFI NPIFEFSRAM RRLGLDDAEY ALLIAINIFS ADRPNVQEPG RVEALQQPYV EALLSYTRIK RPQDQLRFPR MLMKLVSLRT LSSVHSEQVF ALRLQDKKLP PLLSEIWDVH E
Protein Image