Human NR1H3/LXRA Protein (Ligand Binding Domain [AA215-667]), Made in E.coli, with His Tag

Human NR1H3/LXRA Protein (Ligand Binding Domain [AA215-667]), Made in E.coli, with His Tag

SKU Description Size Price Shipping  
OP10471 Human NR1H3/LXRA Protein (Ligand Binding Domain [AA215-667]), Made in E.coli, with His Tag 10µg $257 Immediate Add To Shopping Cart
OP10472 Human NR1H3/LXRA Protein (Ligand Binding Domain [AA215-667]), Made in E.coli, with His Tag 25µg $513 Immediate Add To Shopping Cart
Other VersionsNR1H3, with His Tag
NR1H3, with GST Tag
NR1H3 (N-terminal domain [AA1-182]), with His Tag
NR1H3 (Ligand binding domain [AA215-667]), with His Tag
NR1H3 (Ligand binding domain [AA215-667]), with GST Tag
Datasheet
DescriptionLiver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids . There are two subtypes of LXRs, LXRa and LXRß. LXRa is preferentially expressed in liver, small intestine, kidney and spleen . In contrast, LXRß expression is ubiquitous . The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system . Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function . LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes (6-8), including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP) (9-10). The ligand binding domain (LBD) of LXR determines ligand specificity and mediates the trans-activation function of the receptor .
Gene ID10062
Gene NameNR1H3
AliasLXR-a, LXRA
Host SpeciesHuman
Production HostE.coli
TagsHis Tag
Purity> 95% as determined by SDS-PAGE
Bio Activity1 unit equals 1 nanogram purified protein. 20 units are sufficient for a gel-mobility shift assay and 100 units are sufficient for a protein-protein interactions assay.
EndotoxinNot Tested
Formulation20 mM Tris-Cl (pH 7.9) 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA
Concentration300 µg/ml
ReconsitutionAlready in liquid form.
Storage-80 °C
ShippingDry Ice
Background
GenBank Accession #: NM_005693
Amino Acid Sequence:
EKLVAAQQQC NRRSFSDRLR VTPWPMAPDP HSREARQQRF AHFTELAIVS VQEIVDFAKQ LPGFLQLSRE DQIALLKTSA IEVMLLETSR RYNPGSESIT FLKDFSYNRE DFAKAGLQVE FINPIFEFSR AMNELQLNDA EFALLIAISI FSADRPNVQD QLQVERLQHT YVEALHAYVS IHHPHDRLMF PRMLMKLVSL RTLSSVHSEQ VFALRLQDKK LPPLLSEIWD VHE
Protein Image