Human ESR1 Protein (Estrogen Receptor), Made in Sf21 Insect Cell, with His Tag

Human ESR1 Protein (Estrogen Receptor), Made in Sf21 Insect Cell, with His Tag

SKU Description Size Price Shipping  
OP10571 Human ESR1 Protein (Estrogen Receptor), Made in Sf21 Insect Cell, with His Tag 4µg $429 Immediate Add To Shopping Cart
OP10572 Human ESR1 Protein (Estrogen Receptor), Made in Sf21 Insect Cell, with His Tag 10µg $857 Immediate Add To Shopping Cart
Other VersionsBiotin-labeled and heavy-labeled (C13 and N15) versions of this protein are also available. Please contact us for more information.
Datasheet
DescriptionSeveral members of the nuclear receptor family are directly associated with human malignancies including breast cancer, prostate cancer and leukemia. The pathogenesis of each of these diseases is underpinned by the activities of a member of the superfamily; estrogen receptor-alpha (ER alpha) in breast cancer, androgen receptor (AR) in prostate cancer, and retinoic acid receptor alpha (RAR alpha) in acute promyelocytic leukemia . Estrogen receptors (ER) are members of the superfamily of nuclear hormone receptors whose activity is required for the normal function of the female reproductive system. Two isoforms of estrogen receptor (ER a and ER ß) have been described. They function as ligand-dependent transcriptional activators . The biological functions downstream of ER result from altered expression of direct transcriptional targets as well as secondary effects mediated by biological activities of direct targets. In the mammary gland, estrogen receptors regulate normal epithelial cell development and differentiation through their well-documented effects on transcription . Estrogens have long been known to have mitogenic functions in breast cancer cell lines and in breast tumors . Selective estrogen receptor modulatory compounds (SERMs), which bind directly to ER, can block the growth stimulatory function of estrogens .
Gene ID2099
Gene NameESR1
AliasER, ESR
Host SpeciesHuman
Production HostSf21 Insect Cell
TagsHis Tag
Purity> 95% as determined by SDS-PAGE
Bio Activity1 unit is equal to 1 nanogram of purified protein. 20-100 units are sufficient for an in vitro transcription assay and 100 units are sufficient for a protein-protein interaction assay.
EndotoxinNot Tested
Formulation20 mM Tris-Cl (pH 7.9) 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA
Concentration200 µg/ml
ReconsitutionAlready in liquid form.
Storage-80 °C
ShippingDry Ice
Background
GenBank Accession #: NM_000125
Amino Acid Sequence:
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA VYNYPEGAAY EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL NSVSPSPLML LHPPPQLSPF LQPHGQQVPY YLENEPSGYT VREAGPPAFY RPNSDNRRQG GRERLASTND KGSMAMESAK ETRYCAVCND YASGYHYGVW SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC RLRKCYEVGM MKGGIRKDRR GGRMLKHKRQ RDDGEGRGEV GSAGDMRAAN LWPSPLMIKR SKKNSLALSL TADQMVSALL DAEPPILYSE YDPTRPFSEA SMMGLLTNLA DRELVHMINW AKRVPGFVDL TLHDQVHLLE CAWLEILMIG LVWRSMEHPG KLLFAPNLLL DRNQGKCVEG MVEIFDMLLA TSSRFRMMNL QGEEFVCLKS IILLNSGVYT FLSSTLKSLE EKDHIHRVLD KITDTLIHLM AKAGLTLQQQ HQRLAQLLLI LSHIRHMSNK GMEHLYSMKC KNVVPLYDLL LEMLDAHRLH APTSRGGASV EETDQSHLAT AGSTSSHSLQ KYYITGEAEG FPATV
Protein Image
SDS-PAGE alysis of recombint ESR1