Human NR1H2 Protein (Ligand Binding Domain LBD [AA211-461]), Made in E.coli, with His Tag

Human NR1H2 Protein (Ligand Binding Domain LBD [AA211-461]), Made in E.coli, with His Tag

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OP10661 Human NR1H2 Protein (Ligand Binding Domain LBD [AA211-461]), Made in E.coli, with His Tag 10µg $310 Immediate Add To Shopping Cart
OP10662 Human NR1H2 Protein (Ligand Binding Domain LBD [AA211-461]), Made in E.coli, with His Tag 25µg $620 Immediate Add To Shopping Cart
Other VersionsNR1H2, with His Tag
NR1H2, with GST Tag
NR1H2 (Ligand Binding Domain [AA211-461]), with His Tag
NR1H2 (Ligand Binding Domain [AA211-461]), with GST Tag
Datasheet
DescriptionLiver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids . There are two subtypes of LXRs, LXRa and LXRß. LXRß is preferentially expressed in liver, small intestine, kidney and spleen . In contrast, LXRa expression is ubiquitous . The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system . Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function . LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes (6-8), including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP) (9-10). LXRß expressed in livers of LXRa knockout mice does not compensate for the loss of LXRa . In addition, LXRß, but not LXRa, is also able to activate transcription of a reporter gene, which contains a specific direct repeat separated by 1 bp (DR1) element in the promoter, suggesting that LXRß may have different biological functions .
Gene ID7376
Gene NameNR1H2
AliasLXR-b, LXRB
Host SpeciesHuman
Production HostE.coli
TagsHis Tag
Purity> 95% as determined by SDS-PAGE
Bio Activity1 unit equals 1 nanogram of purified protein. 20-100 units are sufficient for a ligand binding assay and 100 units are sufficient for a protein-protein interaction assay.
EndotoxinNot Tested
Formulation20 mM Tris-Cl (pH 7.9) 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA
Concentration700 µg/ml
ReconsitutionAlready in liquid form.
Storage-80 °C
ShippingDry Ice
Background
GenBank Accession #: NM_007121
Amino Acid Sequence:
GSGEGEGVQL TAAQELMIQQ LVAAQLQCNK RSFSDQPKVT PWPLGADPQS RDARQQRFAH FTELAIISVQ EIVDFAKQVP GFLQLGREDQ IALLKASTIE IMLLETARRY NHETECITFL DFTYSKDDFH RAGLQVEFIN PIFEFSRAMR RLGLDDAEYA LLIAINIFSA DRPNVQEPGR VEALQQPYVE ALLSYTRIKR PQDQLRFPRM LMKLVSLRTL SSVHSEQVFA LRLQDKKLPP LLSEIWDVHE
Protein Image
SDS-PAGE alysis of recombint NR1H2