Human NCOA1/SRC1 Protein (Receptor Interaction Domain [AA627-786]), Made in E.coli, No Tag

Human NCOA1/SRC1 Protein (Receptor Interaction Domain [AA627-786]), Made in E.coli, No Tag

SKU Description Size Price Shipping  
OP10871 Human NCOA1/SRC1 Protein (Receptor Interaction Domain [AA627-786]), Made in E.coli, No Tag 10µg $409 Immediate Add To Shopping Cart
OP10872 Human NCOA1/SRC1 Protein (Receptor Interaction Domain [AA627-786]), Made in E.coli, No Tag 25µg $818 Immediate Add To Shopping Cart
Other VersionsNCOA1 with No Tag
NCOA1 with No Tag, Biotinylated
NCOA1 with His Tag
NCOA1 with His Tag, Biotinylated
NCOA1 with His Tag (TEV Cleavable)
NCOA1 with FLAG Tag (TEV cleavable)
NCOA1 with GST Tag
Datasheet
DescriptionSteroid receptor coactivator 1 (SRC1) is a transcriptional coactivator that mediates the activating functions of many of the nuclear hormone receptors. It is also known as NCoA1 and is a member of the SRC/p160 coactivator family . SRC1 has been shown to be over expressed in some cancers . SRC1 is a 160 kDa protein that contains several LXXLL motifs, which are involved in nuclear receptor interaction . The region 627-786 contains 3 LXXLL motifs that are involved in interaction with nuclear hormone receptors and have been previously used in assays detecting ligand-dependent receptor-cofactor interactions . This protein is not tagged and will be useful for assays where a native untagged protein is desired.
Gene ID8648
Gene NameNCOA1
AliasSRC1, bHLHe74
Host SpeciesHuman
Production HostE.coli
TagsNo Tag
Purity> 95% as determined by SDS-PAGE
Bio Activity1 unit equals 1 nanogram of purified protein. 100 units are sufficient for a protein-protein interaction assay.
EndotoxinNot Tested
Formulation20 mM Tris-Cl (pH 7.9) 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA
Concentration400 µg/ml
ReconsitutionAlready in liquid form.
Storage-80 °C
ShippingDry Ice
Background
GenBank Accession #: NM_003743
Amino Acid Sequence:
GGSQTSHKLV QLLTTTAEQQ LRHADIDTSC KDVLSCTGTS NSASANSSGG SCPSSHSSLT ERHKILHRLL QEGSPSDITT LSVEPDKKDS ASTSVSVTGQ VQGNSSIKLE LDASKKKESK DHQLLRYLLD KDEKDLRSTP NLSLDDVKVK VEKKEQMDPC NT
Protein Image
SDS-PAGE alysis of recombint NCOA1