Human EP300/P300 Protein [AA1135-2414], Made in Sf21 Insect Cell, with His Tag

Human EP300/P300 Protein [AA1135-2414], Made in Sf21 Insect Cell, with His Tag

SKU Description Size Price Shipping  
OP20121 Human EP300/P300 Protein [AA1135-2414], Made in Sf21 Insect Cell, with His Tag 4µg $409 Immediate Add To Shopping Cart
OP20122 Human EP300/P300 Protein [AA1135-2414], Made in Sf21 Insect Cell, with His Tag 10µg $818 Immediate Add To Shopping Cart
Other VersionsSame Protein, Full-length version. Same Protein CH1[AA302-531] version.
Biotin-labeled and heavy-labeled (C13 and N15) versions of this protein are also available. Please contact us for more information.
Datasheet
DescriptionHuman p300 and CBP (CREB binding protein) are highly related transcriptional coactivators. Both proteins have been identified through protein interaction assays . In addition to interacting with a variety of cellular factors and onco-proteins, loss of the wild type CBP alleles in isolated tumors suggests that CBP/p300 might serve as a tumor suppressor . The C-terminus of p300 contains a histone acetyltransferase (HAT) domain expanded from residues 1195 to 1673, an activation domain (residues 1763-1812) that interacts with many transcription factors and an SRC-1 domain further down stream of the activation domain. P300 is able to acetylate histones and many other transcription factors, including p53, E2F, TFIIE, and TFIIF etc. implicating diverse roles of p300 in gene regulation.
Gene ID2033
Gene NameEP300
AliasKAT3B, RSTS2
Host SpeciesHuman
Production HostSf21 Insect Cell
TagsHis Tag
Purity> 95% as determined by SDS-PAGE
Bio Activity1 unit equals 1 nanogram of purified protein. 50 units are required for a reconstituted transcription assay and 100 units are required for a protein-protein interaction assay.
EndotoxinNot Tested
Formulation20 mM Tris-Cl (pH 7.9) 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA
Concentration350 µg/ml
ReconsitutionAlready in liquid form.
Storage-80 °C
ShippingDry Ice
Background
GenBank Accession #: NM_001429
Amino Acid Sequence:
KTSRVYKYCS KLSEVFEQEI DPVMQSLGYC CGRKLEFSPQ TLCCYGKQLC TIPRDATYYS YQNRYHFCEK CFNEIQGESV SLGDDPSQPQ TTINKEQFSK RKNDTLDPEL FVECTECGRK MHQICVLHHE IIWPAGFVCD GCLKKSARTR KENKFSAKRL PSTRLGTFLE NRVNDFLRRQ NHPESGEVTV RVVHASDKTV EVKPGMKARF VDSGEMAESF PYRTKALFAF EEIDGVDLCF FGMHVQEYGS DCPPPNQRRV YISYLDSVHF FRPKCLRTAV YHEILIGYLE YVKKLGYTTG HIWACPPSEG DDYIFHCHPP DQKIPKPKRL QEWYKKMLDK AVSERIVHDY KDIFKQATED RLTSAKELPY FEGDFWPNVL EESIKELEQE EEERKREENT SNESTDVTKG DSKNAKKKNN KKTSKNKSSL SRGNKKKPGM PNVSNDLSQK LYATMEKHKE VFFVIRLIAG PAANSLPPIV DPDPLIPCDL MDGRDAFLTL ARDKHLEFSS LRRAQWSTMC MLVELHTQSQ DRFVYTCNEC KHHVETRWHC TVCEDYDLCI TCYNTKNHDH KMEKLGLGLD DESNNQQAAA TQSPGDSRRL SIQRCIQSLV HACQCRNANC SLPSCQKMKR VVQHTKGCKR KTNGGCPICK QLIALCCYHA KHCQENKCPV PFCLNIKQKL RQQQLQHRLQ QAQMLRRRMA SMQRTGVVGQ QQGLPSPTPA TPTTPTGQQP TTPQTPQPTS QPQPTPPNSM PPYLPRTQAA GPVSQGKAAG QVTPPTPPQT AQPPLPGPPP AAVEMAMQIQ RAAETQRQMA HVQIFQRPIQ HQMPPMTPMA PMGMNPPPMT RGPSGHLEPG MGPTGMQQQP PWSQGGLPQP QQLQSGMPRP AMMSVAQHGQ PLNMAPQPGL GQVGISPLKP GTVSQQALQN LLRTLRSPSS PLQQQQVLSI LHANPQLLAA FIKQRAAKYA NSNPQPIPGQ PGMPQGQPGL QPPTMPGQQG VHSNPAMQNM NPMQAGVQRA GLPQQQPQQQ LQPPMGGMSP QAQQMNMNHN TMPSQFRDIL RRQQMMQQQQ QQGAGPGIGP GMANHNQFQQ PQGVGYPPQQ QQRMQHHMQQ MQQGNMGQIG QLPQALGAEA GASLQAYQQR LLQQQMGSPV QPNPMSPQQH MLPNQAQSPH LQGQQIPNSL SNQVRSPQPV PSPRPQSQPP HSSPSPRMQP QPSPHHVSPQ TSSPHPGLVA AQANPMEQGH FASPDQNSMLSQLASNPGMA NLHGASATDL GLSTDNSDLN SNLSQSTLDI H
Protein Image