Human EP300/P300 Protein (P300-CH1 [AA302-531]), Made in E.coli, with His Tag

Human EP300/P300 Protein (P300-CH1 [AA302-531]), Made in E.coli, with His Tag

SKU Description Size Price Shipping  
OP20221 Human EP300/P300 Protein (P300-CH1 [AA302-531]), Made in E.coli, with His Tag 10µg $313 Immediate Add To Shopping Cart
OP20222 Human EP300/P300 Protein (P300-CH1 [AA302-531]), Made in E.coli, with His Tag 25µg $624 Immediate Add To Shopping Cart
Other VersionsSame Protein, Full-length version. Same Protein [AA1135-2414] version.
Biotin-labeled and heavy-labeled (C13 and N15) versions of this protein are also available. Please contact us for more information.
Datasheet
DescriptionHuman p300 and CBP (CREB binding protein) are highly related transcriptional coactivators. Both proteins have been identified through protein interaction assays . In addition to interacting with variety of cellular factors and onco-proteins, loss of the wild type CBP alleles in isolated tumors suggests that CBP/p300 might serve as tumor suppressors . The ability of p300 to acetylate many transcription factors, including p53, E2F, TFIIE, and TFIIF etc. demonstrated a novel mechanism of targeted p300 regulation of gene expression.
Gene ID2033
Gene NameEP300
Aliasp300, KAT3B
Host SpeciesHuman
Production HostE.coli
TagsHis Tag
Purity> 95% as determined by SDS-PAGE
Bio Activity1 unit equals 1 nanogram of purified protein. 1-5 units are sufficient for a gel mobility shift assay in a 20µl reaction; 50-100 units are sufficient for reconstituted transcription assay and 100-200 units are sufficient for a protein-protein interaction assay or an acetylation assay.
EndotoxinNot Tested
Formulation20 mM Tris-Cl (pH 7.9) 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA
Concentration1000 µg/ml
ReconsitutionAlready in liquid form.
Storage-80 °C
ShippingDry Ice
Background
GenBank Accession #: NM_001429
Amino Acid Sequence:
MGQQPAPQVQ QPGLVTPVAQ GMGSGAHTAD PEKRKLIQQQ LVLLLHAHKC QRREQANGEV RQCNLPHCRT MKNVLNHMTH CQSGKSCQVA HCASSRQIIS HWKNCTRHDC PVCLPLKNAG DKRNQQPILT GAPVGLGNPS SLGVGQQSAP NLSTVSQIDP SSIERAYAAL GLPYQVNQMP TQPQVQAKNQ QNQQPGQSPQ GMRPMSNMSA SPMGVNGGVG VQTPSLLSDS
Protein Image