Human HIF1A Protein (HIF-1a, C-terminal activation domain CTAD [AA776-826]), Made in E.coli, with His Tag

Human HIF1A Protein (HIF-1a, C-terminal activation domain CTAD [AA776-826]), Made in E.coli, with His Tag

SKU Description Size Price Shipping  
OP20251 Human HIF1A Protein (HIF-1a, C-terminal activation domain CTAD [AA776-826]), Made in E.coli, with His Tag 10µg $310 Immediate Add To Shopping Cart
OP20252 Human HIF1A Protein (HIF-1a, C-terminal activation domain CTAD [AA776-826]), Made in E.coli, with His Tag 25µg $620 Immediate Add To Shopping Cart
Other VersionsBiotin-labeled and heavy-labeled (C13 and N15) versions of this protein are also available. Please contact us for more information.
Datasheet
DescriptionHypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. HIF-1 alpha contains two transactivation domains located between amino acids 531 and 826. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified. Specific disruption of the HIF-1 pathway is important for exploring its role in tumor biology and developing more efficient weapons to treat cancer . HIF-1alpha is a master regulator of the hypoxic response, and its proangiogenic activities include, but are not limited to, regulation of vascular endothelial growth factor (VEGF) . HIF-1alpha protein expression is often seen in invasive breast cancer . Recent data demonstrates that HIF-1alpha knockdown reduces tumorigenicity of MCF-7 cells and suggests a promising combination of both anti-HIF-1 strategy and traditional chemotherapy to improve cancer treatment .
Gene ID3039
Gene NameHIF1A
AliasPASD8, HIF-1alpha
Host SpeciesHuman
Production HostE.coli
TagsHis Tag
Purity> 95% as determined by SDS-PAGE
Bio ActivityN/A
EndotoxinNot Tested
Formulation20 mM Tris-Cl (pH 7.9) 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA
Concentration700 µg/ml
ReconsitutionAlready in liquid form.
Storage-80 °C
ShippingDry Ice
Background
GenBank Accession #: NM_001530
Amino Acid Sequence:
MAHHHHHHAS SDLACRLLGQ SMDESGLPQL TSYDCEVNAP IQGSRNLLQG EELLRALDQV N
Protein Image