Recombinant PCSK9 Proteins and Mutants - SPEED BioSystems

Recombinant PCSK9 Proteins and Mutants

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Cytokines

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a proprotein. Up activation, it binds to low-density lipoprotein (LDL) receptor, inducing its degradation and thus prevent removal of LDL cholesterol from blood. Blocking PCSK9 with monoclonal antibodies, peptide mimics or inhibitors can lower circulating LDL cholesterol level and reduce risk of cardiovascular diseases. PCSK9 is a drug target. Many drugs targeting PCSK9 have been approved or in late stage clinical trials.

SPEED Biosystems provides the following forms of high quality recombinant PCSK9 proteins.


SKU Protein Name Species Amino Acid Sequence Production Host Tags Note
YCP1057 PCSK9 Human Gln31-Gln692 of UniProt Q8NBP7 HEK293 His
YCP5715 PCSK9 Human Gln31-Gln692 of UniProt Q8NBP7 HEK293 Strep
YCP5721 PCSK9 Human Gln31-Gln692 of UniProt Q8NBP7 HEK293 His R194A mutant
YCP5723 PCSK9 Human Gln31-Gln692 of UniProt Q8NBP7 HEK293 His D374Y mutant
YSP7237 PCSK9 Human Gln31-Gln692 of UniProt Q8NBP7 HEK293 AVI(Biotin)
YSP7239 PCSK9 Human Gln31-Gln692 of UniProt Q8NBP7 HEK293 His/HA/AVI
YCP1593 PCSK9 Human Ser153-Gln692 of UniProt Q8NBP7 HEK293 His Mature Form
YCP1591 PCSK9 Human Gln31-Gln152 of UniProt Q8NBP7 HEK293 No Tag
YCP5711 PCSK9 Cynomolgus Gln31-Gln692 of UniProt G7NVZ1 HEK293 His
YCP5713 PCSK9 Rhesus Gln31-Gln692 of UniProt A8T666 HEK293 His
YCP5717 PCSK9 Mouse Gln35-Gln694 of UniProt Q80W65 HEK293 His
YCP5719 PCSK9 Rat Gln31-Gln692 of UniProt P59996 HEK293 His
YCP6053 PCSK9 Hamster Gln30-Ser691 of UniProt G3GTK5 HEK293 His