Anti-human ERBB2 / Her2 monoclonal antibody, trastuzumab biosimilar

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PRODUCT

  • SKU

    DMS1068-100ug

  • Size

    100ug

  • Price

    $350

1
This antibody is part of a collection of biosimilar antibodies in reference to those approved or in clinical investigation. The biosimilars are for Research Use Only and should not be used in therapeutic or diagnostic procedures in humans or animals.
note Other commonly used names in publications refering to this antibody: 4D5-8, 4D5V8, Herceptin, rhuMabHER2
target ERBB2 / Her2
alias ERBB2, CD340, HER-2/neu, HER2, MLN19, NEU, NGL, TKR1
gene id Uniprot ID: P04626
host species Humanized
reactivity Human
iso type Human IgG1 kappa
formulation Lyophilized from sterile PBS, pH 7.4. Typically, 5% - 8% trehalose is added as a protective agent prior to lyophilization.
reconstitution Reconstitute lyophilized powder with water to a concentration of 100 ug/ml
applications ELISA, Flow Cyt
dilution ELISA 1:5000-10000; Flow Cyt 1:100
shipping Shipped at ambient conditions.
storage Lyophilized form is stable for 1 week at room temperature. Store at -20 °C to -80 °C for 12 months in lyophilized form. After reconstitution, store at 4 °C for 2-7 days or at below -20 °C for up to 3 months.

Images

Flow cytometry analysis with 15 ug/mL Anti-Her2 (trastuzumab biosimilar) mAb on Expi293 cells transfected with Human Her2 protein (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).

ELISA plate pre-coated by 1 ug/mL (100 uL/well) Human Her2, His tagged protein binds to Anti-Her2 (trastuzumab biosimilar) mAb in a linear range of 3.2-400 ng/ml.

ELISA plate pre-coated by 1 ug/mL (100 uL/well) Human Her2 Protein, hFc Tag binds to Anti-Her2 (trastuzumab biosimilar) mAb in a linear range of 3.81-1730.10 ng/mL.

Flow cytometry analysis of antigen binding of anti-human Her2 mAb. (A) The antibody does not bind to Jurkat cells that do not express Her2. (B) A clear peak shift of The antibody was seen compared to the control when incubated with Her2-expressing MCF-7 cells, indicating strong binding of The antibody to Her2. Antibodies were incubated at 2 ug/mL.


PRODUCT

  • SKU

    DMS1068-100ug

  • Size

    100ug

  • Price

    $350

1