Anti-human CD33 monoclonal antibody, gemtuzumab biosimilar

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PRODUCT

  • SKU

    DMS1031-100ug

  • Size

    100ug

  • Price

    $350

1
This antibody is part of a collection of biosimilar antibodies in reference to those approved or in clinical investigation. The biosimilars are for Research Use Only and should not be used in therapeutic or diagnostic procedures in humans or animals.
note Other commonly used names in publications refering to this antibody: CDP-771, CMA-676, WAY-CMA-676,
target CD33
alias CD33, SIGLEC3, gp67
gene id Uniprot ID: P20138
host species Humanized
reactivity Human
iso type Human IgG4 kappa
formulation Lyophilized from sterile PBS, pH 7.4. Typically, 5% - 8% trehalose is added as a protective agent prior to lyophilization.
reconstitution Reconstitute lyophilized powder with water to a concentration of 100 ug/ml
applications Flow Cyt
dilution Flow Cyt 1:100
shipping Shipped at ambient conditions.
storage Lyophilized form is stable for 1 week at room temperature. Store at -20 °C to -80 °C for 12 months in lyophilized form. After reconstitution, store at 4 °C for 2-7 days or at below -20 °C for up to 3 months.

Images

HEK293 cell line transfected with irrelevant protein (B) and human CD33 (A) were surface stained with anti-CD33 neutralizing antibody 1ug/ml (gemtuzumab) followed by Alexa 488-conjugated anti-human IgG secondary antibody.

Flow cytometry analysis of antigen binding of anti-human CD33 mAb. (A) A clear peak shift of The antibody was seen compared to the control when incubated with CD33-expressing 8226 cells, indicating strong binding of The antibody to CD33. Antibodies were incubated at 2 ug/mL.

Flow cytometry analysis of antigen binding of anti-human CD33 mAb. (A) The antibody does not bind to 293T cells that do not express CD33. (B) A clear peak shift of The antibody was seen compared to the control when incubated with CD33 -expressing THP-1 cells, indicating strong binding of The antibody to CD33 . Antibodies were incubated at 5 ug/mL.


PRODUCT

  • SKU

    DMS1031-100ug

  • Size

    100ug

  • Price

    $350

1